Skip to main content

chris richards

Richards and Pauly Awarded funds for Research on Therapeutic Targeting in Nicotine Addiction

Assistant Professor Chris Richards (UK Chemistry) and Professor James Pauly (UK Pharmacy) have been awarded funding to help elucidate the mechanism of nicotine addiction and to identify targets for nicotine cessation therapeutics. The $760,000 grant awarded by the National Institutes of Health is titled "Single Molecule Determination of nAChR Structural Assembly for Therapeutic Targeting.”

Biomolecular Capture and Transport Through Synthetic Nanopores


Abstract: Nanopores are miniaturized electrical sensors with arguably the smallest detection volumes (sub-yoctometers, or below 10-24 m3).[1]Detection of molecules using nanopores involves electrical monitoring of ion current flow through a pore using a pair of electrodes placed across the nanopore-containing membrane. Our group focuses on the use of nanopores that range from 1 to 10 nm in all dimensions (diameter and thickness). We fabricate such nanopores using a combination of state-of-the-art ultrathin membrane fabrication and focused electron beam irradiation using a transmission electron microscope. Recently, we have found that nanopore dimensions critically determine the quality of detection and discrimination of biomolecules. I will talk about our efforts to distinguish different types of tRNA molecules, RNA-drug complexes,[2]and proteins[3]. In addition, I will mention our efforts to control DNA transport through nanopores, useful for genomic mapping.[4]Finally, I will mention our studies that probe nucleosomal interactions and influence by epigenetic factors,[5]as well as our latest efforts in combining nanopores and optical waveguides for direct DNA sequencing from picogram-level genetic material

CP - 114
Type of Event (for grouping events):
Subscribe to chris richards